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KMID : 0371320040670040325
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Journal of the Korean Surgical Society
2004 Volume.67 No. 4 p.325 ~ p.329
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Gastric Cancer Diagnosed in a Patient with Extramammary Paget’s Disease
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Lee Si-Hak
Kim Hyun-Yul
Jeon Tae-Yong
Kim Dong-Heon
Sim Mun-Sup
Kim Moon-Bum
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Abstract
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Extramammary Paget’s disease (EMPD) is a rare intraepithel ial neoplasm arising in apocrine gland-bearing skin. EMPD may be regarded as a skin marker of associated malignancy because it tends to combine a variety of underlying malignancies in up to 50% of cases. Herein a case of gastric cancer diagnosed in a patient with extramammary Paget’s disease of the scrotum is reported. The patient was a 65-year-old man whose chief complaint was exanthema of the right scrotum of 3 years duration. Biopsy samples taken from patient showed large, round cells with clear cytoplasm in the epidermis. The final diagnosis was EMPD of the scrotum. The extensive workups, including tumor marker, imaging studies and endoscopy to exclude associated malignancy were performed. Examination of the endoscopic gastric biopsy spec-imen revealed an adenocarcinoma of the stomach. On the basis of this result, a radical subtotal gastrectomy was suc-cessfully performed. This case suggests that, in cases of EMPD, the clinicians should consider the possibility of underlying malignancies and thoroughly examine not only the urogenital tract and lower gastrointestinal tract, but also the visceral organs, such as the stomach, even if there are no clinical symptoms of malignancy.
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